2024 Volume 46 Issue 2 Pages 96-101
Background. Cryptococcosis is a deep-seated mycosis caused by a capsular yeast infection with Cryptococcus sp.. Cryptococcus sp. mainly infects the lungs and central nervous system, and laryngeal and tracheal lesions are rare. Case. An 82-year-old woman was diagnosed with Hodgkin lymphoma in January X−3 and achieved a complete response after chemotherapy. Computed tomography (CT) of the chest taken in May X to monitor lymphoma progress revealed a nodular shadow in the lower lobe of the right lung and coughing and hoarseness started simultaneously. Blood tests were positive for Cryptococcus neoformans antigen, and bronchoscopy was performed for a diagnosis. A biopsy of the right S6 node and nodular protrusions in the trachea was performed. C. neoformans was culture-positive in the tissue, and cryptococcosis was diagnosed. After treatment with fluconazole, the patient's hoarseness improved, the pulmonary nodular shadow was reduced on chest CT, and bronchoscopy showed improvement of the laryngeal and tracheal lesions. Conclusion. When cryptococcosis is suspected in immunocompetent patients, it is important to check for bronchial and laryngeal lesions.
