Abstract
Two cases with transient factor V inhibitor developing after partial liver resection and the surgical use of Tacho Comb® (bovine fibrin glue sheet) are reported. In both cases, prothrombin time (PT) and activated partial thromboplastin time (APTT) significantly prolonged at approximately 10 days after the operations. Plasma factor V acitivities in both patients prominently decreased. The prolongation of PT and APTT sustained for 20-30days and then spontaneously recovered. Both patients did not have any bleeding symptoms at this periods. Tacho Comb® contains bovine thrombin and fibrin and is widely being used to arrest of hemorrhage at bleeding surface. Tacho Comb® contaminated bovine factor V, detected by Western blotting. It is suggested that the patients produced the antibody against bovine factor V and this antibody cross-reacted to human factor V antigen and inhibited the factor V activity. So it has been necessary of attention to appearance of factor V inhibitor following the use of Tacho Comb®.
