Blocked blood vessel model for the development of treatment device of retinal vein occlusion

Abstract

Retinal Vein Occlusion is caused by thrombus formation. Retinal arteries and arterioles and their corresponding veins share a common adventitial sheath. It is considered that the thickening of the arteriole compresses the vein, eventually causing thrombus formation. Current treatment methods are not direct removal of thrombus, only symptomatic treatment. For the present study, the micro-vascular of the chicken embryo was employed as a retina vein occlusion phantom as a simple model of alive blood vessel. Artificial blood clot was produced by the mixture of the fibrinogen, thrombin and blood of the venous thrombus component. This study will contribute to produce a library of a wide range of properties of blood clot to evaluate the developed mechanical medical devices.