Abstract
The reptilase time of 61 patients with hepatic disease, i. e. chronic hepatitis (21 cases), cirrhosis (29 cases) and others (11 cases) was estimated by the modified method of reptilase R clotting time. Also relationship of level between the reptilase time and some such factors as the following was studied in hepatic diseases described above: Thrombin time, prothrombin time, FDP and various substances for the liver function test.
The results obtained are as follows.
1. Almost half number of patients with chronic hepatitis and cirrhosis revealed prolongation of the thrombin time. While, most cases of the same diseases described above showed prolongation of the reptilase time.
2. The patients with cirrhosis in whom the reptilase time was prolonged revealed relatively high levels of ZTT and GOT.
3. The patients with cirrhosis, showing high level of about 100 Karmen in GOT or 12 units in ZTT, has significantly prolonged reptilase and thrombin times.
4. A less correlation was found between the fibrinogen levels estimated by the clot weight method and thrombin or reptilase time in patients with chronic hepatitis and cirrhosis.
5. FDP was found in many cases of chronic hepatitis and cirrhosis, but not so much that the thrombin time or reptilase time was influenced by FDP.
It is concluded that a tendency of prolongation of the reptilase time is of value for screening for active form of cirrhosis.
