Abstract
Fibrinolytic effects of Defibrase (Batroxobin) administered into a patients with Barger's disease and four normal adults are obserbed in this paper.
On the cases for single injection with Batroxobon (0.8-1.6BU/kg) into four normal adults, the fibrinogen in plasma is not detected by usual method between 8 and 24hrs after injection, and then it increases gradually. However, the concentration of FDP including X, Y, D and E fragments indicated by immunoelectrophoretic technique, with plasmin activity measures more than 1, 000μg/ml between 4 and 48hrs after injection and the levels of plasminogen and α2-plasmin inhibitor show the lowest values between 8 and 13hrs and decrease to 40-50% and 20-30% respectively.
On the case of Barger's disease treated with continuous administration of Batroxobin (0.5-0.9BU/kg), the factors of fibrinolytic system shows the same tendencies as single shot data of normal cases and those tendencies are kept continuously during the treatment with Batroxobin. Furthermore, in general the plasma after the injection with Batroxobin clots spontaneously, when it has been collected in the test-tubes, and it is analyzed that the clot consists of des-A fibrinogen which was digested into X fragment of FDP and crosslinked of γ-chain of des-A fibrinogen in paraclot. Therefore, it is presumed that this phenomenon might be one kind of enzymatic paracoagulation of plasmin-digested des-A fibrinogen with or without fibrinogen by the exsisting of the very small amount of snake venom and activated factor XIII.
