Abstract
The platelet specific protein, β-thromboglobulin (β-TG) is released into the circulation when blood platelets undergo the release reation.
Plasma β-TG levels in several thrombotic diseases were measured by radio-immunoassay kit (Radiochemical Centre).
The results were as follows,
1) Normal β-TG levels was 33.6±22.6 (±SD) ng/ml (n=29).
2) In arterial and venous thrombosis, β-TG levels were significantly increased in comparision with normal levels.
3) In several thrombotic diseases, β-TG levels were usualy increased after U. K. therapy.
But, in effective case of U. K., β-TG levels were decreased to normal range.
4) In other thrombotic diseases, for example, diabetes mellitus and malignant diseases (carcinoma etc.), β-TG levels were significantly increased.
5) We could find the negative correlation between β-TG and platelet count in PRP.
Conclusion:
From the above results, it's concluded that plasma β-TG levels shows signicant increase and closely related to platelet count in thrombotic diseases.
We also found that the measurement of β-TG is a good indicator to evaluate the effectiveness of thrombolytic therapies.
