Behavior of rat stomach kallikrein-like substance in experimental gastric ulceration occurrence

Abstract

Fibrinolysis, coagulation, and kinin system relate to pathogenesis of gastric ulcer. Serum kinin has complicated backgrounds and its changes are not in accordance with pathogenesis of gastric ulcer. The relationships between tissue-fibrinolysis and tissue-kallikrein were studied in tissue-plasminogen activator and tissue-kallikrein.
Recently, kallikrein has been found in stomach tissue. Synthetic substrate, Prolyl-Phenyl-Arginyl-Naphtyl-Ester, was used to determine its activity. It was studied whether its value reflects clearly tissue-kallikrein or not.
Satisfactory results were obtained in the basic study. Then an experiment of stress ulcer due to water immersion was performed with DONRYU rat. In the study on a relationship between tissue-plasminogen activator and tissue-kallikrein during the term from preloading state to the development of ulcer, tissue-kallikrein was reduced and reduction of tissue-plasminogen activator was also observed.