Abstract
Burn injuries cause dynamic alterations of the coagulative and fibrinolytic activities of the blood. But there has been little research in this field.
In our research of burned patients who sustained burns over 30% of the total body surface area, platelet counts, PT, PTT, fibrinogen, ELT, fibrinolytic activities on various fibrin plates, FDP, α1-antitrypsin, α2-macroglobulin and antithrombin III were checked.
The results show that intravascular coagulation occurs soon after burn injury and it takes almost one month, including the passage through the hypercoagulative stage to normalize. So we devided the postburn period into 4 stages from the hematological standpoint.
Ist stage; within 48 hours. IInd stage; 3rd-7th day.
IIIrd stage; 8th-30th day. IVth stage; after 30th day.
We used heparin of 10, 000-20, 000U in dose on burned patients clinically to prevent the DIC in the Ist stage. From our experience, heparin therapy to burned patients is very effective and safe. But in severly burned patients, administration of FOY is recommended.
