Abstract
The functional disparities between heparin and MDS are studied in this paper and the following results are obtained;
1) Although heparin shows no effect on thrombin time test using purified human fibrinogen with human thrombin, the addition of MDS to the mixture of thrombin time test indicates the inhibitory effect on the clotting time.
2) Heparin accelerates the inhibitory effect on amydolitic action of thrombin with AT-III, but MDS mixed with or without AT-III does not show any influences on the amydolitic action of thrombin.
3) By the use of crosselectrophoretic technique the complex formation of MDS with AT-III is not demonstrated, but heparin with AT-III showes the complex formation of them. However, both MDS and heparin does not show the complex formation with thrombin alone.
4) The mixture of heparin and prothrombin showes no complex formation even in exsistence with AT-III, but the mixture of MDS and prothrombin forms a complex, which proves no effect on prothrombin-thrombin conversion by echis carinatus venom.
5) MDS indicates the complex formation with fibrinogen, but heparin does not.
According to the results mentioned above it is recognized that, there are some disparities between MDS and heparin in amydolitic and electrophoretic behaviour, and also in thrombin time test.
