Abstract
Some experiments were studied in order to clarify whether abnormal coagulation in liver cirrhosis and hepatoma may be due to abnormal fibrinogen or not. Abnormal fibrinogen might be suggested by prolonged and decreased fibrin monomer polymerization with thrombin or reptilase.
The purified fibrinogen revealed same abnormal patterns which look like in plasma.
It was suggested that these defects in fibrinogen were associated with delayed polymerization of the fibrin monomer.
However, immunoelectrophoresic study of the purified fibrinogen showed no abnormality and S. D. S-polyacrylamide gel electrophoresis of them showed normal mobility and amount of Aα, Bβ and γ-chains.
Sialic acid content of them were examined in order to detect its character.
It became clear that its content were higher in the patients fibrinogen than in normal controls.
From these results, it may be supposed that there is functionally the abnormal fibrinogen in some patients with liver disease and the high sialic acid content might play an important role in the abnormal coagulation.
