Abstract
Two remarkable hematological features during the last trimester of pregnancy are high coagulability and low fibrinolysis, and many reports have dealt with the former. In this paper, behaviors of fibrinolytic system in pregnant women were mainly studied.
The following factors in the coagulation-fibrinolytic system, namely, PT, PTT, fibrinogen, AT III, α2PI, α1AT, α2M, C3, C4, plasminogen and inhibitory activity to plasmin were assayed in 30 cases of pregnant women of ten month's gestation with the same number of non-pregnant women as control. Observations of platelet aggregation are also reported here. The results obtained are as follows.
1) Fibrinogen, PT (%), α1AT, inhibitory activity were significantly increased, but antigen and activity of AT III were remarkably decreased in the pregnant women as compared with the controls.
2) PTT, α2PI, α2M, C3, C4 and plasminogen were not different with those of the controls.
3) The platelet functions were observed in ten cases. Rates of ADP-and epinephrine-induced platelet aggregation were higher in them than in the controls, but rate of collagen-induced platelet aggregation was not different.
These results indicate that the hypercoagulability was so apparent but low fibrinolysis was not so distinguished as had been expected in the blood of pregnant women of ten months' gestation.
