Abstract
Coagulation and fibrinolysis was investigated in 14 patients with ulcerative colitis, 3 patients with colonic tuberculosis, 2 patients with Crohn's disease, 3 patients with ischemic colitis, 5 patients with aphtoid colitis and 4 patients with radiation-induced proctitis.
The results were as follows: (1) Hypercoagulability was found in the most patients with ulcerative colitis and radiation-induced proctitis. (2) Platelet count was strikingly increased in the patients with active ulcerative colitis. (3) Level of antithrombin III was decreased in the patients with ischemic colitis, ulcerative colitis and radiation-induced proctitis. Moreover, serum plasminogen activity was decreased in the patients with active ulcerative colitis and radiation-induced proctitis and it returned to normal value in patients with ulcerative colitis in remission. On the other hand, fibrin/fibrinogen degradation products of serum was increased in the patients with active ulcerative colitis and Crohn's disease.
The results indicate that hypercoagulability and increased fibrinolytic activity exist in the patients with inflammatory bowel diseases.
