Abstract
Problems in the Urokinase (UK) therapy, were marked difference of the sensitivity against UK in case by case, and hypercoagulability induced by UK administration in some cases. Then, utilizing Urokinase resistant time (UKRT) that indicates the sensitivity against UK, we deviced the method for determination of the optimal administration dose. Furthermore, we used UKRT to monitor the blood coagulation fibrinolysis after UK administration. Twenty three cases of cerebral thrombosis were treated by rapid venous drip infusion of calculated UK doses. All cases were obtained optimal fibrinolytic state without bleeding. Eighteen cases (78%) showed excellent or good clinical results, in which UKRT were shortened between 6 to 10min. at 1 to 3 hours after UK administration. Only increased fibrinolysis might be induced in these cases. Five cases (22%) showed no change or poor clinical results, in which UKRT was prolonged, and then occurrence of hypercoagulability and increased fibrinolysis were suspected.
In conclusion, UKRT may be practically available for the determination of optimal UK doses and monitoring the fibrinolytic therapy.
