Abstract
Highly concentrated F. VIII materials (HC F. VIII) for replacement therapy to hemophilia A contain less amount of fibrinogen than cryoprecipitates. It has become easy to administer a large amount of F. VIII, but there may be some problems in cases of multitransfusion that the starting material of these HC F. VIII is a large scaled pool plasma.
Seventy-one cases of hemophilia A under the frequent replacement therapy by HC F. VIII were investigated on liver function tests and F. VIII inhibitor through 10.2±2.7 months. The mean of total amount of F. VIII administered for individuals within the investigated term are 21, 700±20, 400 units.
Comparative study of GOT, GPT and γ-GTP before and after following-up term showed no significant changes statistically. Both the titer of HBs antibody and the number of HBs antibody positive patients proved increasing tendency, which might be explained with a high titer of HBs and HBc antibody contained in HC F. VIII. F. VIII inhibitory titer showed mild increasing tendency statistically, it may be too early to conclude that the phenomena caused by the multitransfusion of these materials. Because, the mean of the highest titer of these individuals through the objective term is considerably high, 0.903±0.375 unit and 34 out of 71 cases showed over 1.0 unit once at least through the whole course of the objective term.
