Abstract
Platelet adhesion to subendothelium is impaired in Bernard-Soulier syndrome and von Willebrand's disease. Therefore glycoprotein I of platelet membrane and von Willebrand factor in plasma has been reported to have some significant role on platelet adhesion. In this report, platelet adhesion to cellulose ester membrane (millipore membrane filter: MF) as a artificial surface was observed in patients with Bernard-Soulier syndrome, von Willebrand's diseae, afibrinogenemia and normal adults. In normal adults, there was no signigicant difference of adhesion rates between MF and subendothelium, which were 64.7±9.3% (n=5, mean±SD) to MF and 69.4±8.6% to subendotheluim. In Bernard-Soulier syndrome the rate were 7.0±1.4% (n=2, mean±SD) to MF and 11.3±1.8% to subendothelium. However, in von Willebrand's disease, platelet adhesion to MF was almost normal. The adhesion rate was 58±27% (n=4, mean±SD) in contrast to 11.3±1.8% to subendothelium.
The role of von Willebrand factor was not thought to be significant in platelet adhesion to MF, and the effects of other factors, for example electronical charge or microstructures of the surface were thought to relate.
