Studies on the localization of antithrombin III in human vessel

Abstract

The localization of antithrombin III (AT III) in human vessel was investigated by fluorecent antibody method.
The authors found a single layer of AT III on the surface of the intima of the arteries. This fact suggested that a conformational change inducing an increase in antithrombin activity of AT III was caused by heparinoids on the surface of the intima, and that thrombin was regulated by the progressive type of AT III on the surface of the vessels.