Abstract
Effects of the antiplatelet drug, ticlopidine (600mg/day, p. o.) on the anginal attacks of effort or rest angina pectoris by placebo-controlled single blind randomized-cross over method. In 5 patients with rest angina refractory to the conventional method (Ca-antagonists, beta-blockers, isosorbide dinitrates), during ticlopidine therapy, frequencies of anginal attacks and doses of nitroglycerin were both decreased. However, in 5 patients with effort angina, using the Bruce treadmill test, no beneficial effects were observed.
