Abstract
Platelet functions and blood coagulability in the administration of antiplatelet drugs were investigated to find the best method of antithrombogenic therapy at the early postoperative period in 49 patients with prosthetic valves.
The administration modus of antiplatele drugs was divided into three groups; Group A (control), Group B (dipyridamole 300mg/day), Group C (ticlopidine 300mg/day), Group D (ticlopidine 600mg/day). Together with antiplatelet drugs, warfarin was given all patients 3 days after surgery, and prothrombin time PT was maintained at about 30 percent.
Results: PT was recovered to about 80% at 3p. o. d. and Pl aggregation also recovered within 5p. o. d. Both parameters showed thereafter significant increases. Pl. with larger size than 25μ were increased after prosthetic valve replacement, and this increase was also suppressed by antiplatelet drugs. In general Pl. activity and blood coagulability showed a significant increase at the early period after operations. Therefore, antithrombogenic therapy using antiplatelet drugs should be started as soon as plssible after the operation.
