Abstract
Albumin-deficient rat mutant was discovered among Sprague-Dawley rat (SDR) with hypercholosterolemia by Nagase in 1977. In these Nagase's analbuminemic rats (NAR), albumin in plasma is congenitally lacking and an increase in serum globulin concentration is observed. Extreme hyperlipidemia can be induced in NAR by cholesterol-rich diet. In this study, levels of procoagulants, heparin cofactor (antithrombin III), immediate antiplasmin and platelet aggregability of twenty-seven female NAR were compared with those of nine female SDR. In NAR, levels of factors XII, XI, IX and VIII, fibrinogen, antithrombin III and immediate antiplasmin in plasma were significantly higher than in SDR. There was no significant increase in concentrations of factors X, V, II and XIII and platelet aggregability induced by ADP or collagen between SDR and NAR. Levels of factors XII, V, II and XIII, antithrombin III and immediate antiplasmin were higher in SDR and NAR than in human, whereas activities of factors XI, IX, VIII and platelet aggregability were higher in human than in SDR and NAR. Parallel increase in levels of procoagulants and antithrombin III in NAR compared with SDR suggests the presence of homeostatic balance in coagulability of blood in these rat mutants.
