Abstract
To evaluate the clinical efficacy of administration of high dose of urokinase in acute myocardial infarction, we deviled the patients into three groups (high, moderate, and low dose of urokinase). Dose of intravenously dripping urokinase is less than 50×104 unit in low dose group (Group A), 50×104-150×104 unit in moderate dose group (Group B), and 150×104-300×104 unit in high does group (Group C). Following clinical data was examined; 1) serum CPK 2) size of myocardial infarct area (ΣST of ECG) 3) aneurysmal formation and asynergy 4) hemodynamic factors (CI, PAEDP, SWI, TPRI and Double Product).
There was no significant difference in normalizing days of serum CPK between Group A and Group C. Concerning percent changes of ΣST, decrease rate was significantly larger in Group C than in other Group on the 1.5th hospital days (p<0.05) and on the 3rd days (p<0.01) after administration of urokinase. In Group C, aneurysmal formation was not seen and less score of asynergy (AHA criteria) revealed in left ventricular angiogram. Though CI, PAEDP and SWI were more improved in 7 hospital days in Group C than in other groups, there was no difference in TPRI and DP among three groups.
We conclude that high dose of urokinase is effective on reduction of infarct area and amelioration of cardiac function in acute myocardial infarcion.
