Abstract
Concentrations of fibrinogen, plasminogen, antithrombin-III, α1-antitrypsin, α2-macroglobulin, C1-inhibitor and α2-antiplasmin in plasma of arteriosclerosis obliterans, thromboangitis obliterans, deep venous thrombosis and Raynaud's syndrome were measured by radial immunodiffusion except α2-antiplasmin assayed using amidolytic substrate S-2251 (Table 1).
Concentrations of each factor in each disease were compared with that of other disease. The correlation between antigen level or activity of each factor and prognosis in arterial occlusive diseases was investigated (Fig. 1). The average diseased years were 2.9±1.7 (SD) yrs in ASO and 7.2±4.3 (SD) yrs in TAO. The patients aggravated in the course of treatment were designated as poor cases.
On ASO was there correlation between prognosis and concentrations of fibrinogen or C1-inhibitor (Fig. 1). On TAO, significant correlation was identified between prognosis and antigen levels of fibrinogen, α1-antitrypsin or C1-inhibitor (Fig. 1).
It has been reported that C1-INH interacts with C1s, plasmin, kallikrein, factor XIIa and XIa. The role of C1-INH on thrombogenesis and thrombolysis remains uncertain.
In a group with raised levels of C1-INH antigen, a large percent of patients with ASO underwent limb amputation (P<0.05), and patients with TAO had suffered from aggravating ischemic toe ulcers (P<0.05).
On both ASO and TAO, the patients with raised levels of C1-INH antigen resulted in unfavorable prognosis (P<0.01-0.02).
