Abstract
Changes in blood coagulation and fibrinolysis due to hepatic ischemia by using mongrel dogs were investigated.
Under the heparinized hydrophilic catheter-bypass between splenic and femoral vein, the hepatoduodenal ligament was ligated to interrupt hepatic blood inflow in 5 dogs, and temporary interruption of hepatic blood inflow for 15, 30, 60, 90 minutes was performed in each of 5 dogs.
In this experimental study, changes of systemic blood coagulation and fibrinolysis, and histological changes of liver were investigated periodically.
Continuous interruption of hepatic blood inflow decreased blood coagulability gradually. Temporary interruption of hepatic blood inflow for more than 60 minutes caused remarkable decrease of blood coagulability after declamping, and histologically fibrin deposits were found in sinusoid and portal vein of Glisson's area, indicating that apparent DIC occured in the liver at more than 60 minutes after clamping. One hour after declamping of 90 minutes interruption of hepatic blood inflow, most of fibrin deposits disappeared, but degeneration of endothelial cell of sinusoid and hepatocyte indicating the disturbance of hepatic microcirculaion by which caused acute liver failure and systemic DIC were observed, thereby finally led to death of shock.
