Changes of thromboxane B₂ in surgical operations

Abstract

Plasma thromboxane B₂ were investigated in various diseases; arteriosclerosis obliterans (ASO), thromboangitis obliterans (TAO), abdominal aortic aneurysm (AAA) and malignant diseases. TxB₂ changes due to arterial recostructive surgery and general surgery were invetigated.
The results obtained were as fallows.
1) TxB₂ level was significantly increased in the patients with TAO or malignant diseases, and was increased in ASO, AAA compared with healthy control.
2) TxB₂ was significantly increased during operations and postoperative periods in arterial reconstructive surgery and general surgery.
3) There was significant positive correlation between TxB₂ and β-TG (p<0.01).
4) TxB₂ was elevated during operations, so it suggests that platelet activity was vivid during operations.