Studies on hemostatic findings and effect of small dose of aspirin administration with or without dilazep in patients with prosthetic heart valves

Abstract

Platelet survival time by MDA method, platelet functions and some coagulation parameters were examined in 45 patients with prosthetic valves. These parameters were also measured after administration of aspirin (40mg/day) with or without dilazep (300mg/day) for 4 weeks, in 22 of these 45 patients. All patients except one were under warfarin treatment, and the mean value of thrombo-test was 20.9% (8.5-85%).
The following results were obtained;
1) Platelet survival time was decreased in 26 (57.8%) of these patients.
2) After administration of aspirin with or without dilazep, platelet aggregability was suppressed significantly.
3) Platelet survival time was prolonged after 4 weeks of administration of aspirin with dilazep, as compared with that obtained before treatment.
These results suggest that small dose of aspirin with dilazep may prevent thrombo-embolic complications in these patients with prosthetic heart valves.