Abstract
A family of congenital dysfibrinogenemia, in which the propositus comlicated acute occlusion in the left side internal carotid artery and four out of nine tested family members had abnormal fibrinogen with no history of thrombosis is reported. The abnormal fibrinogen was characterized by a defective polymerization in the formation of fibrin.
The occlusive thrombus that had been formed in the carotid artery shown by angiogram, could be removed by the fibrinolytic therapy with the local infusion of urokinase. It is suggested that the dysfibrinogenemia might be easily dissolved by fibrinolysis because of the poor polymerization.
