Abstract
The influence of disseminated intravascular coagulation (DIC) on major organs was studied in dogs. Endotoxin was intravenously infused in dogs over 90 minutes at a dose of 2mg/kg to induce DIC. The parameter used to evaluate this influence were WBC, platelet counts, levels of fibrin degradation products, plasminogen, antiplasmin, antithrombin III, S-GOT, S-GPT, S-BUN and S-Creatinine, prothrombin time, microcirculations in the liver and kidney, and respiration rate over a period of four hours.
Immediately after the onset of DIC, microcirculation in the liver was markedly decreased, while S-GOT and S-GPT were increased. S-BUN and S-Creatinine were also elevated although microcirculation in the kidney remained normal.
These findings demonstrate that multiple organ failure (MOF) should be treated as soon as DIC is suspected or diagnosed.
