Abstract
Changes in platelet counts, prothrombin time, partial thromboplastin time, thrombo test, normo test (hepaplastin test), fibrinogen, euglobulin lysis time (ELT) and Bβ 15-42 peptide were investigated on 16 patients with benign disease and 27 with malignant disease before and after operation in general surgical patients. The same investigation was performed on 6 patients with benign disease and 29 with malignant disease who had intermittent sequential compression of the legs for 48 hours postoperatively.
The 125I-fibrinogen uptake test was performed on 45 patients with malignant disease who had intermittent sequential compression of the legs for 48 hours postoperatively.
Following results were obtained.
1) It suggests that influence on activity of plasminogen activator was produced by leg compression but no influence on activity of plasmin and plasminogen was produced by leg compression.
2) Incidence of deep vein thrombosis (DVT) in intermittent sequential leg compression group reduced to 8.9 per cent compared with 18.0 per cent in control group.
