Abstract
The third degree burn covering 35% of the total body surface area was made on the back of rabbits, and the animal were divided into 6 groups and the effectiveness of OP-41483, aspirin (ASA: high dose), ASA (low dose), OKY-046 and CV-4151 on arachidonate cascade after burn injury were studied. Examinations of thromboxane B2 (TX) and 6-keto prostaglandin F1α (PG) showed the increase of TX and TX/PG ratio in infusion therapy group. On the contrary, TX/PG ratio was decreased in OP-41483, ASA (large dose), OKY-046 and CV-4151 groups. Only OP-41483 prevented the decrease of platelet count after burn injury while other drugs did not prevented the decrease. The organ failure after burn injury, such as renal failure, has close relation with alterations of acachidonate cascade, so the drugs which decrease TX absolutely or relatively may effective to prevent the renal insufficiency after the burn injury. From the results of this experiment, TX synthetase inhibitors such as CV-4151 and OKY-046 prevented the increase of TX and increased PG and decreased TX/PG ratio extrmely.
