Abstract
Anticoagulant activity by a new synthetic substrate (MD805) during the hemodialysis can be assessed with the direct determination of plasma level. The result of an assay with a chromogenic substrate as antithrombin activity proved to be reproducible and precise levels on plasma samples taken in the hemodialysis with MD805 anticoagulation. Higher plasma level of MD805 during the hemodialysis than theoretical plasma concentration as that of APTT by the addition of MD805 in vitro. Therefore, the assay obtained from in vitro study was needed to obtain the same prolongation of plasma level of MD805 in hemodialysis could be introduced to individual requirement of the optimal dose of MD805 for the maintenance of adequate anticoagulation.
