Age-related change of the concentrations of plasminogen, α₂PI and t-PA antigen, and PA activity in plasma

Abstract

Age-related increase has been observed in thrombotic disease. A change in fibrinolysis activity may play an important part in the pathogenesis of thrombotic disease. Therefore, this study was designed to investigate age-related changes in the plasma levels of fibrinolysis factors including plasminogen, α₂PI and t-PA antigen as well as the plasma PA activity.
The plasma level of α₂PI was negatively correlated with age in both sexes. This age-related decline was more obvious in male (r=-0.515) than female (r=-0.268). The plasma plasminogen level and PA activity did not differ depending on age. The t-PA antigen concentration showed a positive correlation with age in female (r=0.650) and in male (r=0.463).