Platelet aggregation in whole blood using screen filtration rate method in the survivors of cerebral infarction

Abstract

Platelet aggregometry in whole blood in both 24 normal controls and 57 survivors of cerebral infarction (CI) was performed by our new method, i. e. screen filtration rate method (SFR). SFR was based on the phenomenon that platelet aggregates in blood samples cease the natural flow of specimen through the metal micromesh. Several concentrations of ADP were used as inducer of platelet aggregation. Platelet aggregability was graded according to the minimum concentration of ADP which induce irreversible platelet aggregation.
Platelet aggregation in whole blood in CI patients was more readily occurred than that in platelet rich plasma. Spontaneous platelet aggregation, which was considered to play a important role in causing a ischemic episode, was often observed in whole blood of survivors. We conclude that platelet aggregation in whole blood should be studied to disclose the mechanism of thrombus formation.