Abstract
We examined ultrastructurally the postmortem tissues to search for AIDS virus from a patient with hemophilia B who developed AIDS. Tissues fixed in 10% formalin were processed to prepare specimens for electron microscopic study. Round particles, 100-110nm in diameter, with a centric or eccentric nucleoid, were observed frequently in the intra and extracellular spaces of the lymph node, liver and spleen. These particles were morphologically identical with the mature AIDS virus. The budding virions on the plasma membranes were also found in the liver. Besides these findings, two types of cytoplasmic inclusion bodies were observed: One was “tubuloretucular structure (TRS)” seen in the liver, and the other “test tube and ring shaped forms (TRF)”, observed in the lymph node. These findings were the same as we previously described with another hemophiliac who died of AIDS, but not so many as the other specimens treated with glutaraldehyde.
