Abstract
It has been suggested in experimental animal cancer system that platelet aggregating potential of cancer cell and platelet aggregating material (PAM) is one of the most important factor in cancer metastasis. We established a human lung cancer cell line (KUM·LK-2) which produce spontaneous lung metastasis in nude mouse. PAM was extracted from KUM·LK-2 cell and PAM owned aggregating potential in human heparinized-PRP. PAM was differ from well known aggregating materials like ADP, collagen and others. PAM didn't contain fibrinogen and sialic acid, and was not concerned witht hromboxan composition. PAM was considered high molecular weight protein itself containing phospholipid and aggregating potential was concerned with ATP composition of platelet. This was first confirmation of platelet aggregating potential in human cancer cell line which own metastatic potential. Platelet aggregating potential of KUM·LK-2 cell may play a important role in blood borne metastasis.
