1978 Volume 9 Issue 2 Pages 169-173
Hepaplastintest, thrombotest, prothrombin time and blood coagulation factors II, V, VII, VIII, IX and X were measured in 9 cases with fulminant hepatitis, in 34 cases with acute hepatitis and in mice with MHV-2 hepatitis. Also carbon index as pagocytic activity was measured in mice with MHV-2 hepatitis. The following results were obtained.
1) The activities of the blood coagulation except for factor VIII showed a decrease in fulminant hepatitis and in acute stage of acute hepatitis as compared to healthy subjects, especially in fulminant hepatitis.
2) In acute hepatitis including fulminant hepatitis, there was a correlation between the decrease of the activities of blood coagulation except for factor VIII and severity of the disease.
3) In mice with MHV-2 hepatitis, the activities of the blood coagulation except for factor VIII decreased with the progression of hepatic necrosis. But the activities of factor VIII increased in early stage, and decreased in terminal stage of MHV-2 hepatitis with parallel to the pagocytic activity.
Therefore, it is believed that the determination of blood coagulation tests in hepatitis is useful to determine the diagnosis and prognosis of the diseases, and that the changes of factor VIII in MHV-2 hepatitis are closely related to the function of RES.
