1978 Volume 9 Issue 2 Pages 191-196
We have studied the changes of blood coagulation and fibrinolysis in 47 patients with gastric cancer undergoing preoperative antineoplasmic chemotherapy. We also have studied the relation between the plasma fibrinogen level and histological stage of the cancer. The control group was 17 patients of gastric cancer without preoperative treatment.
1. There was no remarkable changes in the platelet count and fibrinolysis.
2. Prothrombin time was slightly prolonged in the patients treated with 5-Fluorouracil Dry Syrup (5-FUDS) therapy, but its level was still within normal limit, and there was no significant difference in loss of blood during operation between the patients with 5-FUDS therapy and control group.
3. Plasma fibrinogen level decreased in the patients with 5-FUDS therapy and five times combined Mitomycin C and 5-Fluorouracil (MF) therapy. The decrease in fibrinogen level was more prominent in the patients with histologically advanced cancer. This fact was perhaps due to the antineoplasmic effect of these drugs to gastric cancer. On the other hand, there was no decrease in fibrinogen level in control group and in 3-4 times MF group.
