1978 Volume 9 Issue 2 Pages 202-207
It was noted that the coagulative and the fibrinolytic faculties of the Japanese monkey were similar to those of the human in our previous report.
In the present paper, we have measured the movement of the blood coagulative and fibrinolytic faculties after the intravenous injection of the tissue thromboplastin by using Japanese monkeys in an attempt to induce the experimental disease of disseminated intravascular coagulation (DIC).
The results were as follows;
1) In the coagulation system, platelet and fibrinogen level decreased extremely at first 10min after the injection, and tended to recover their level gradually from about 60min later in the case of the injection of the small (10mg/kg) and middle (20mg/kg) dose of tissue thromboplastin.
But in the case of the high dose (40mg/kg), the level of platelet and fibrinogen did not recovered.
The prolongation of the PT, PTT and TT were found from 10min after the injection, and the recovery of those clotting time was depended on the fibrinogen level.
It seems that the degree of response and recovery of these results depend upon the dose of tissue thromboplastin.
2) In the fibrinolysis system, the PLT and ELT were extremely reduced at 10min after the injection, and its reduction was induced by smaller dose of tissue thromboplastin as compared with that in the coagulation system.
The appearence of FDP and the positive reaction in paracoagulation test were observed later from the reduction of PLT and ELT.
3) Fibrillar thrombosis with ultrastructual appearance were found in small pulmonary vessels by the injection of even small dose of tissue thromboplastin.
