Influence of coagulant and antifibrinolytic agents on coagulation and fibrinolysis after pulmonary cancer operation

Abstract

Coagulation and fibrinolysis system is important on the release and stickness of criculating cancer cells after the cancer operation. We showed that pulmonary metastasis was protected by decrease of platelets, inhibition of platelet function and inducement of fibrinolytic activity in rat.
According to those experimental studies, Influence of coagulant and antifibrinolytic agents on coagulo-fibrinolytic system after operation were investigated in pulmonary cancer cases. Inspite of un-used coagulant agents, we observed that fibrinolytic activity was decreased, antiplasmin activity was increased and adhesitveness of platelets was enhanced.
The difference of coagulant agents used groupes and un-used groupes was not recognized. It is suported that the anti-coagulant and Fibrinolytic agents is better than the coagulant and antifibrinolytic agents for cacer operation.