Urokinase induced shortness of euglobulin lysis time and its clinical significance

Abstract

Study was dealed with the shortness of euglobulin lysis time (ELT) induced by adding urokinase to euglobulin fraction. After adding each of urokinase with 0.1, 0.2 and 0.4 units to euglobulin fraction, ELT was measured by use of ordinary method. Original ELT shorten by adding UK in vitro was expressed as UK-ELT. The ratio of UK-ELT to original ELT was calculated for knowing the degree of UK induced ELT.
1) In original ELT between 101 and 2, 000 minutes, the shortness of ELT was observed to parallel to the concentration of UK in vitro. But there was no effect on the shortness of ELT accelerated within 100 minutes. When original ELT showed with over 2, 001 minutes, a little shortness of ELT was observed in original ELT prolonged more than 2, 001 minutes.
2) Positive correlation was found between UK-ELT and the amount of fibrinogen that was equivalent to 1mg of plasminogen. The maximum shortness of ELT was obtained by the state of plasminogen rich and considerable amount of fibrinogen in plasma.
3) In acute phase of myocardial infarction, UK-ELT by urokinase of 0.4 units showed 34.8±16.7% in the survival in comparison with 87.3±31.6% in the death. Namely, euglobulin fraction obtained from poor prognostic myocardial infarction remained to be in low response, which was thought to be induced by a lack of plasminogen and a latge amount of fibrinogen. In cerebral haemorrage as well as myocardial infarction, UK-ELT in the death showed 38.3±17.0% of lower response than in 73.3±27.5% of the survival.
4) It was suggested that the prognosis in acute attack of vascular disease could be decided according to UK-ELT might show the result of breakdown of equilibrium between the amount of fibrinogen and plasminogen in plasma.