Differences in Pathophysiology between TF and LPS-induced Rat DIC Model

Abstract

Tissue factor (TF) and lipopolysaccharide (LPS) have been frequently used as inducers disseminated intravascular coagulation syndrome (DIC) in animals experimental models, but the consequences in the animals may not have been assesed from the view point of district entities. In this study, we have attempted to see their characteristic features in the pathophysiology of there two types of DIC models with special reference to selected hemostatic parameters and pathological findings in the kidney. To induce DIC, male Wistar rats were infused with either 3.75U/kg of TF over 1h or 30, 50 or 100mg/kg of LPS over 4h via the tail vein. Characteristis features for the TF-models were significantly elevated D dimer and thrombin-antithrombin III complex (TAT) with mild deposition of fibrin in the kidney. On the other hand, the LPS-infused rats manifested markedly decreased antithrombin III activity and severe fibrin deposition in the kidney. Since the pathological features of these two experimental DIC models are not identical, their experimental data and clinical implications ought to be carefully assessed as distinct entities.