Abstract
We report two cases of irregular antibodies detected after platelet concentrate transfusion.
Pre-transfusion antibody testing was negative in both cases. However, we detected anti-Jkb in case 1, and anti-E in case 2 after platelet concentrate transfusion. The platelet donor was Jk (b+) in case 1, and E (+) in case 2. Therefore, in both cases, a very small amount of red blood cell contamination in platelet concentrate might have caused a primary or secondary immune response.
Usually, we do not choose compatible blood in platelet concentrate transfusion to irregular antibody-positive patients, but sufficient attention should be given to platelet concentrate transfusion in future.
In addition, irregular antibodies with titers which are easy to decrease may be overlooked by pre-transfusion antibody testing.
We look forward to the spread of blood transfusion cards which allow the selection of compatible blood even if irregular antibodies are present at below defectable levels or pre-transfusion antibody testing or when a patient is transfused at another hospital.
