末梢血幹細胞採取におけるSpectra OptiaⓇ MNCモードとCMNCモードの後方視的検討

伊藤 誠; 早瀬 英子; 渡邊 千秋; 上床 貴代; 魚住 諒; 林 泰弘; 早坂 光司; 茂木 祐子; 加畑 馨; 高橋 秀一郎; 宮下 直洋; 後藤 秀樹; 小野澤 真弘; 白鳥 聡一; 杉田 純一; 橋本 大吾; 秋沢 宏次; 佐藤 典宏; 豊嶋 崇徳

doi:10.3925/jjtc.64.742

Originals

FUNCTIONAL COMPARISON BETWEEN Spectra Optia^® MNC AND CMNC MODES FOR PERIPHERAL BLOOD STEM CELL COLLECTION

Makoto Ito, Eiko Hayase, Chiaki Watanabe, Takayo Uwatoko, Ryo Uozumi, Yasuhiro Hayashi, Koji Hayasaka, Yuko Mogi, Kaoru Kahata, Syuichiro Takahashi, Naohiro Miyashita, Hideki Goto, Masahiro Onozawa, Souichi Shiratori, Junichi Sugita, Daigo Hashimoto, Koji Akizawa, Norihiro Sato, Takanori Teshima

Author information

Makoto Ito
Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
Eiko Hayase
Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
Department of Hematology, Hokkaido University Faculty of Medicine
Chiaki Watanabe
Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
Takayo Uwatoko
Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
Ryo Uozumi
Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
Yasuhiro Hayashi
Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
Koji Hayasaka
Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
Yuko Mogi
Clinical Research and Medical Innovation Center, Hokkaido University Hospital
Kaoru Kahata
Department of Hematology, Hokkaido University Faculty of Medicine
Clinical Research and Medical Innovation Center, Hokkaido University Hospital
Syuichiro Takahashi
Department of Hematology, Hokkaido University Faculty of Medicine
Naohiro Miyashita
Department of Hematology, Hokkaido University Faculty of Medicine
Hideki Goto
Department of Hematology, Hokkaido University Faculty of Medicine
Masahiro Onozawa
Department of Hematology, Hokkaido University Faculty of Medicine
Souichi Shiratori
Department of Hematology, Hokkaido University Faculty of Medicine
Junichi Sugita
Department of Hematology, Hokkaido University Faculty of Medicine
Daigo Hashimoto
Department of Hematology, Hokkaido University Faculty of Medicine
Koji Akizawa
Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
Norihiro Sato
Clinical Research and Medical Innovation Center, Hokkaido University Hospital
Takanori Teshima
Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital
Department of Hematology, Hokkaido University Faculty of Medicine

Keywords: peripheral blood stem cell collection, Spectra Optia^®, collection efficiency for CD34-positive cells

JOURNAL FREE ACCESS

2018 Volume 64 Issue 6 Pages 742-751

DOI https://doi.org/10.3925/jjtc.64.742

Details

Abstract

Background: Spectra Optia^® is an apheresis system that enables peripheral blood stem cell collection (PBSCC) to be easily conducted due to its unique automated interface management system. We retrospectively analyzed the number for CD34-positive cells in collected products and the collection efficiency for CD34-positive cells between the Spectra Optia^® MNC mode (MNC group) and CMNC mode (CMNC group) for PBSCC.

Methods: We retrospectively analyzed 233 cases of PBSCC (autologous PBSCC: 103 cases, allogeneic PBSCC: 130 cases), which were performed in our institution between August 2013 and February 2018.

Results: In autologous PBSCC, there was no significant difference in the number of CD34-positive cells in collected products or the collection efficiency for CD34-positive cells between the two groups. In allogeneic PBSCC, the number of CD34-positive cells in collected products and the collection efficiency for CD34-positive cells in the CMNC group were significantly higher than those in the MNC group. Peripheral blood platelet count and hemoglobin concentration were identified as the factors influencing the collection efficiency for CD34-positive cells.

Conclusion: In autologous PBSCC, the number and collection efficiency for CD34-positive cells were not significantly different between the two modes, whereas in allogeneic PBSCC, the CMNC mode was more efficient for PBSCC than the MNC mode.

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