Japanese Journal of Transfusion and Cell Therapy
Online ISSN : 1883-0625
Print ISSN : 1881-3011
ISSN-L : 1881-3011
Case Report
A CASE OF ANTI-D DETECTION AFTER DEL RED BLOOD CELL TRANSFUSION IN AN RhD-NEGATIVE PATIENT
Yuki ChibaAkiko MatsuhashiMana KumetaRyuji ShiraiKeiko OnoderaToshihiro Ohura
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2024 Volume 70 Issue 5 Pages 542-547

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Abstract

We experienced a case in which anti-D was detected in an RhD-negative patient who was transfused with RhD-negative red blood cells (RBC). We requested the Japanese Red Cross Tohoku Block Blood Center to perform a genetic analysis of the blood products used, and found a typical DEL gene (c. 1227G>A) in the donor of the most recently transfused RBC. Since factors other than transfusion were negative for the production of anti-D, it was inferred that transfusion of DEL-type was involved in the production of anti-D. Although the immunogenicity of the DEL-type is considered low, there are scattered reports that transfusion of this type is involved in the production of anti-D. Therefore, it is considered necessary to avoid transfusion of DEL-type RBCs whenever possible to prevent Hemolytic Disease of the Fetus and Newborn (HDFN) in RhD-negative pregnant women and hemolytic transfusion reactions (HTR) in anti-D carriers. Since DEL-type RBCs are also known to carry at least one C antigen, and none have a cc phenotype, the use of D and C antigen negative RBCs for patients described previously is a rational choice in terms of safe transfusion, cost, and supply-demand balance.

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© 2024 The Japan Society of Transfusion Medicine and Cell Therapy
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