Antibody Response of Sika Deer(Cervus nippon)against 4 Kinds of Bovine Vaccine Viruses

Abstract

Adult sika deer(Cervus nippon)were inoculated with bovine viral vaccines[infectious bovine rhinotracheitis(IBR), Akabane disease(AD), bovine virus diarrhea-mucosal disease(BVD-MD) and parainfluenza type 3(PI-3)]to observe clinical signs and serological response. No animal exhibited clinical signs of respiratory and intestinal diseases. Serologic response was monitored using serum neutralization test for IBR, AD and BVD-MD, and hemagglutination inhibition test for PI-3. Except IBR, the antibodies for each virus were detected as early as 2 weeks post-inoculation and in almost all animals remained seropositive for >12 weeks. IBR antibody was not detected consistently by one-time vaccination but after second-time vaccination it was detected and persisted >10 weeks with low titers.