Abstract
This study investigated the effects of grape seed proanthocyanidins extract (GSPE) on bone formation in rat tibia following a low-calcium feeding, by examining the bone density,mineral content, geometry and bone strength. Wistar male rats, 5-week old, were used and divided into 4 groups. The metaphysis tibia bone was analyzed by peripheral Quantitative Computed Tomography (pQCT), and the whole tibia by using material testing machine. Trabecular bone density, trabecular bone mineral content, yCSMI, xSSI and stiffness were increased in GSPE group. Increasing of the bone mass seems to be accompanied by the bone strength.
