Abstract
The Notch signaling pathway is involved in cell fate decisions during development. To explore the role of this signaling cascade in the taste system, we have investigated the expression patterns of Notch signaling genes in fetal and adult mouse tongues using in situ hybridization. These genes are expressed in the developing circumvallate papilla, and in taste cells within adult taste buds. The timing and pattern of embryonic Mash1 and Hes6 expression in particular, with respect to papillary and taste bud morphogenesis and innervation suggests a role for these genes in specifying taste receptor cell lineages. Further, expression of Notch pathway genes in adult taste buds suggests that this signaling system may continue to function in lineage decisions within the constantly renewed population of receptor cells within taste buds.
