Host: The Kyushu Dental Society
Pages 11
The test agent, a newly-developed tooth whitening agent, is used for the waiting room bleaching. It is a mixture of 5% hydrogen peroxide solution and sodium perborate. In this study, the test agent was evaluated on the possibility of allergenicity in mice. It was underwent to examine by the ear swelling test whether the test agent caused type IV allergic reaction. Then the distribution of immunocytes in ears and lymph nodes during the ear swelling test was observed by the indirect enzyme immunoassay. CD4 and CD8 positive cells were detected. In the ear swelling test, the increase of ear thickness was not recognized. There found no difference between the test agent and the control on CD4 and CD8 positive cell numbers in the second examination. The results suggest that the test agent scarcely causes type IV allergy even in human.