Effects of PRP (Platelet Rich Plasma) on human osteoblast like cells

Abstract

PRP has recently applied clinically in the field of oral and maxillofacial surgery for the efficacy of bone regeration, bone augmentation, wound healing. In PRP various kinds of growth factors and cytokines deprived from platelets such as TGF-β, PDGF, IGF, bFGF have been reported to be included a lot by some researchers. In this study we evaluated the effects of PRP on osteoblast like cells, HOS and SaOS-2 examining Alkaline phosohatase activity and cell viability using MTT assay. PRP seemed to enhance the cell viably soon after addition of PRP and have inhibitary effects of ALP activity in the intial peroids.