Immunohistochemical study of tamor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) in an antigen-induced arthritis of the rabbit temporomandibular joint

Abstract

The aim of this study was to investigate tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) immunohistchemically in an antigen-induced arthritis of the rabbit temporomandibular joint. TNF-α was detected in biphasic style, i.e. in acute phase inflammatory cells, synovial cells, subsynovial fibroblasts and chondrocytes were reacted positively, and in chronic phase reproduction of TNF-α was observed in synovial cells and chondrocytes. Immunoreactivities for TNF-α were markedly observed in clustering chondrocytes in chronic phase. Positive reactions for IL-8 in inflammatory cells, synovial cells and chondrocytes were observed only in acute phase of the arthritis.