C38 is a Neuron Specific Mitochondrial Protein that Controls Neuronal Development

Abstract

The retina has a well-organized cellular structure and belongs to the central nervous system. The retina has been used as a model of the central nervous system, especially neuronal degeneration and axonal regeneration. Monoclonal C38 antibody has been used as a molecular marker of retinal ganglion cells, but the molecular function of its antigen has not been clarified. A recent study has demonstrated that C38 is a neuron-specific mitochondrial protein that enhances neuronal maturation. This review outlines the functions of C38, as investigated through a retina model.