2024 Volume 75 Pages 1-5
Cancer treatment methods are diversifying, and in addition to the conventional three major therapies (surgery, chemotherapy, and radiation therapy), immune checkpoint inhibitors and photoimmunotherapy are being applied clinically. While this has improved the outcomes of cancer patients, there are still some patients who cannot receive effective treatment due to side effects, and new cancer treatment strategies are needed to be developed. The diversification of cancer treatment methods is expected to continue, and the development of novel Drug Delivery Systems (DDS) is essential. By electrospinning method, the authors developed a nanofiber sheet that can release chemotherapeutic drugs, and investigated the anti-tumor effect of sustained drug release using a xenograft model of hepatocellular carcinoma. DDS has been developed in three areas: controlled absorption, controlled release, and targeting. In cancer chemotherapy, DDS is an important technology to selectively deliver drugs to cancer tissues to maximize drug efficacy and minimize side effects. This paper outlines the new potential of controlled release DDS in cancer therapy, focusing on our findings.
